Modern craftsmanship shapes the 2026 Mercedes-Benz E 350 Sedan and the 2026 Mercedes-Benz E 450 4MATIC® Sedan from the inside out, pairing elegant design with technology that feels naturally integrated. Turbocharged engines, immersive digital displays, and a thoughtfully appointed cabin set the stage for a driving experience that balances performance, technology, and comfort. Our team at Autohaus on Edens has created this 2026 Mercedes-Benz E 350 Sedan vs. the 2026 Mercedes-Benz E 450 4MATIC® Sedan guide so you can see what makes each stand out.
Take a look at our inventory to find your ideal 2026 Mercedes-Benz E 350 Sedan or 2026 Mercedes-Benz E 450 4MATIC® Sedan. If you prefer to see one or both in person, arrange an appointment or come to our Mercedes-Benz dealership in Northbrook, IL. You can also shop models based on our current lease offers. If you have any questions, contact us online or give us a call at (847) 272-7900.
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Designed to make every mile feel effortless, the 2026 Mercedes-Benz E 350 Sedan and the 2026 Mercedes-Benz E 450 4MATIC® Sedan pair turbocharged performance with mild hybrid efficiency. The 2026 Mercedes-Benz E 350 Sedan features a 2.0L inline four-cylinder (I4) engine that delivers 255 horsepower through rear-wheel drive (RWD) and is capable of achieving up to 33 MPG on the highway.
If you prefer stronger acceleration, the 3.0L inline six-cylinder (I6) engine of the 2026 Mercedes-Benz E 450 4MATIC® Sedan produces 375 horsepower and, with the grip of 4MATIC® all-wheel drive (AWD), is capable of a 0-to-60 MPH time of just 4.4 seconds. DYNAMIC SELECT drive modes and the AGILITY CONTROL® selective damping suspension let you tailor each sedan’s responses to match everything from relaxed commuting to more spirited driving.
Compare the following engine specifications:
| Model | 2026 Mercedes-Benz E 350 Sedan | 2026 Mercedes-Benz E 450 4MATIC® Sedan |
|---|---|---|
| Engine | 2.0L I4 turbo with mild hybrid drive | 3.0L I6 turbo with mild hybrid drive |
| Horsepower | 255 HP | 375 HP |
| Torque | 295 lb.-ft. | 369 lb.-ft. |
| Drivetrain | RWD | 4MATIC® AWD |
| Transmission | 9G-TRONIC nine-speed automatic | 9G-TRONIC nine-speed automatic |
| MPG (City/Hwy) | 25 / 33 | 23 / 33 |
| 0-60 MPH* | 6.1 sec. | 4.4 sec. |
From every angle, the 2026 Mercedes-Benz E 350 Sedan and the 2026 Mercedes-Benz E 450 4MATIC® Sedan present clean body lines and carefully integrated details that emphasize sophistication. Standard AMG® body styling, a Chrome Star-pattern grille, LED lighting, and various available wheel sizes create a distinctive appearance. For everyday convenience, each sedan includes rain-sensing windshield wipers, power-folding side mirrors, and an electronic trunk closer with HANDS-FREE ACCESS. The optional Night Package, offered for both models, includes gloss black accents for an edgier appeal.
Shared exterior features:
The 2026 Mercedes-Benz E 350 Sedan and the 2026 Mercedes-Benz E 450 4MATIC® Sedan provide a cabin that focuses on creating a tranquil atmosphere for every journey. An expansive panorama roof with a tilting and sliding sunroof and 64-color LED lighting allows natural lighting or vibrant colors to shape your interior ambiance. Additionally, heated front seats with optional ventilation and massage, heated rear outboard seats, and a heated steering wheel make it easy to settle into a relaxing position. Leather or Nappa leather upholstery and an Air Balance cabin-air purification and fragrance system are optional, further elevating comfort for every passenger.
Shared interior features:
The proportions of the 2026 Mercedes-Benz E 350 Sedan and the 2026 Mercedes-Benz E 450 4MATIC® Sedan balance spaciousness with practical everyday usability. Their 194.9-inch overall length and 116.6-inch wheelbase contribute to a smooth, composed ride, while 41.5 inches of front legroom provide generous space behind the wheel. A 12.7-cubic-foot trunk gives you room for luggage, shopping bags, or weekend travel essentials, while the 40/20/40-split folding rear seats add flexibility when carrying larger items.
Every interaction with the 2026 Mercedes-Benz E 350 Sedan and the 2026 Mercedes-Benz E 450 4MATIC® Sedan is centered around intuitive digital technology. Two expansive displays work with the Mercedes-Benz User Experience (MBUX) infotainment system, MB Navigation with MBUX Augmented Video for Navigation, biometric authentication, and “Hey, Mercedes” voice activation to simplify access to information, settings, and media while driving. An optional Burmester®** 4D surround sound system with Dolby Atmos® or Apple® Spatial Audio technology creates rich, layered acoustics.
Shared tech features:
Innovative technologies designed to support everyday driving are integrated into the 2026 Mercedes-Benz E 350 Sedan and the 2026 Mercedes-Benz E 450 4MATIC® Sedan. Standard features such as Active Brake Assist, Blind Spot Assist with Exit Warning Assist, and PARKTRONIC with Active Parking Assist help simplify common driving situations. Both models can be equipped with an optional Driver Assistance Package that adds over ten additional systems, including advanced assistance for highway travel. Exclusive to the 2026 Mercedes-Benz E 450 4MATIC® Sedan is a Four-Wheel Electronic Traction System (4ETS®), which pairs with 4MATIC® AWD for enhanced stability and control.
Shared driver assistance and safety features:
If you’re ready to see the 2026 Mercedes-Benz E 350 Sedan and the 2026 Mercedes-Benz E 450 4MATIC® Sedan in person, you’ll find a selection of new sedans waiting in our inventory. Reserve a test drive or visit us in Northbrook at your convenience to experience their performance, craftsmanship, and technology from behind the wheel. Reach out to our team online or by phone at (847) 272-7900 if you have any questions.
*Stated rates of acceleration are based upon manufacturer’s track results and may vary depending on model, environmental and road surface conditions, driving style, elevation and vehicle load.
**Burmester is a registered trademark of Burmester Audiosysteme GmbH, Berlin, Germany.
†Bluetooth® is a registered mark of Bluetooth® SIG, Inc.
